Cortisol Test (Serum Cortisol Level)

The Cortisol Test at Pamel Laboratories measures the level of cortisol, a vital hormone produced by the adrenal glands. Cortisol plays an essential role in regulating metabolism, blood pressure, immune response, and the body’s stress response.

This test is crucial for diagnosing adrenal gland disorders, such as Cushing’s syndrome (excess cortisol) or Addison’s disease (cortisol deficiency), and for evaluating symptoms related to chronic stress, fatigue, and hormonal imbalances.

What the Test Measures:

• The concentration of cortisol in the blood at a specific time of day

• Assesses adrenal gland function and the body’s stress hormone levels

Purpose of the Test:

• Diagnose or monitor:

  • Cushing’s syndrome (hypercortisolism)

  • Addison’s disease (adrenal insufficiency)

  • Adrenal tumors or pituitary gland disorders

• Evaluate symptoms such as:

  • Persistent fatigue or weakness

  • Unexplained weight changes

  • Low blood pressure or salt craving

  • High blood sugar or excessive body fat (especially in the face and abdomen)

Sample Type: Blood sample (serum)
Fasting Required: Yes, and morning sample (between 7–9 AM) is typically preferred for accuracy
Turnaround Time: Same day or within 24 hours

Interpretation Guide:

• Normal range varies depending on the time of day (cortisol peaks in the morning and declines by night)

• High cortisol: May suggest Cushing’s syndrome, stress, or adrenal tumors

• Low cortisol: May indicate Addison’s disease, pituitary insufficiency, or adrenal fatigue

A follow-up ACTH stimulation test or dexamethasone suppression test may be recommended for further evaluation.