Glucose-6-Phosphate Dehydrogenase (G6PD) Test

The G6PD Test at Pamel Laboratories measures the activity level of the Glucose-6-Phosphate Dehydrogenase (G6PD) enzyme in red blood cells. G6PD plays a vital role in protecting red blood cells from damage. A deficiency can lead to the breakdown of red blood cells (hemolysis) when exposed to certain foods, infections, or medications.

This test is essential for diagnosing G6PD deficiency, a genetic disorder more common in males and in certain populations. It helps prevent hemolytic anemia by guiding appropriate treatment and avoiding triggers.

What the Test Measures:

• The enzyme activity level of G6PD in red blood cells

• Assesses the risk or presence of G6PD deficiency

Purpose of the Test:

• Diagnose G6PD deficiency

• Investigate unexplained symptoms such as:

  • Fatigue or weakness

  • Jaundice (yellowing of the skin or eyes)

  • Dark-colored urine

  • Rapid heart rate or shortness of breath

• Prevent hemolytic episodes before prescribing certain drugs (e.g., antimalarials, sulfa drugs) or during infection or stress

• Evaluate newborns with prolonged jaundice

Sample Type: Blood sample (whole blood in EDTA)
Fasting Required: No
Turnaround Time: 1–2 working days

Important Notes:

• Low G6PD activity confirms deficiency; normal levels may require retesting after hemolytic episodes

• Certain medications and foods like fava beans should be avoided in G6PD-deficient individuals

• Early detection helps prevent life-threatening hemolytic crises